New sesquiterpenoid derivatives from Solanum septemlobum with cytotoxicities Lei Zhang, Hai-Qing Lin, Gui-Sheng Li, Xi-Dian Yue & ShengJun Dai a School of Pharmaceutical Science, Yantai University, Yantai 264005, P.R. China b State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical Coll...

Anthemis wiedemanniana essential oil prevents LPS-induced production of NO in RAW 264.7 macrophages and exerts antiproliferative and antibacterial activities in vitro Filomena Conforti a , Federica Menichini a , Carmen Formisano b , Daniela Rigano b , Felice Senatore b , Maurizio Bruno c , Sergio Rosselli c & Sezgin Çelik d a Department of Pharmaceutical Sciences , University of Calabria , via ...

conclusions our findings indicate that umbelliprenin exhibits concentration-dependent inhibitory effects on various cell types; it is potentially toxic against the ht29, ct26, mcf-7, 4t1, a172, and gl26 cell lines, potentially harmful against bmdscs, and non-toxic against pbmcs. therefore, if our results are approved in the future, umbelliprenin can be an appropriate candidate for developing tr...

There are a significant number of natural product (NP) drugs in development. We review the 100 NP and NP-derived compounds and 33 Antibody Drug Conjugates (ADCs) with a NP-derived cytotoxic component being evaluated in clinical trials or in registration at the end of 2013. 38 of these compounds and 33 ADCs are being investigated as potential oncology treatments, 26 as anti-infectives, 19 for th...

We characterize the natural diagonal almost product (locally product) structures on the tangent bundle of a Riemannian manifold. We obtain the conditions under which the tangent bundle endowed with the determined structure and with a metric of natural diagonal lift type is a Riemannian almost product (locally product) manifold, or an (almost) para-Hermitian manifold. We find the natural diagona...